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Infection and Immunity, July 2003, p. 4171-4174, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4171-4174.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Different Strains of Toxoplasma gondii Induce Different Cytokine Responses in CBA/Ca Mice

Fausto G. Araujo* and Teri Slifer

Research Institute, Palo Alto Medical Foundation, Palo Alto, California 94301

Received 27 September 2002/ Returned for modification 12 March 2003/ Accepted 1 April 2003

To investigate the role that cytokines may have in the development of toxoplasmic encephalitis (TE), the levels of gamma interferon (IFN-{gamma}), tumor necrosis factor alpha (TNF-{alpha}), interleukin-12 (IL-12 ]p40[), IL-10, IL-6, IL-4, and IL-2 in serum were examined in CBA/Ca mice infected with a type II strain (ME49 or FORT) of Toxoplasma gondii. These strains caused severe (ME49) or mild (FORT) TE in CBA/Ca mice. From weeks 1 to 8 of infection, the levels of IL-6, IL-10, IL-12, IFN-{gamma}, and TNF-{alpha} in serum were significantly higher in the ME49-infected mice than in the FORT-infected mice, suggesting a role for these cytokines in the severity of TE in CBA/Ca mice. Since the ME49 and FORT strains are of the same type, our results suggest a role for the parasite in the development of severe TE through the increased production of proinflammatory cytokines and indicate that not all type II strains cause TE.

* Corresponding author. Mailing address: Research Institute, PAMF, 795 El Camino Real, Palo Alto, CA 94301. Phone: (650) 853 4768. Fax: (650) 329 9853. E-mail: araujof{at}pamfri.org.

Editor: J. M. Mansfield

Infection and Immunity, July 2003, p. 4171-4174, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4171-4174.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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