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Infection and Immunity, July 2003, p. 4193-4196, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4193-4196.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Lack of Gender-Specific Antibody Recognition of Products from Domains of a var Gene Implicated in Pregnancy-Associated Plasmodium falciparum Malaria

Anja T. R. Jensen,1 Hanne D. Zornig,1 Caecilie Buhmann,1 Ali Salanti,1 Kwadwo A. Koram,2 Eleanor M. Riley,3 Thor G. Theander,1 Lars Hviid,1 and Trine Staalsoe1*

Centre for Medical Parasitology, Copenhagen University Hospital (Rigshospitalet) and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark,1 Epidemiology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana,2 London School of Hygiene and Tropical Medicine, London, England3

Received 13 November 2002/ Returned for modification 11 February 2003/ Accepted 14 April 2003

Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.

* Corresponding author. Mailing address: Department of Infectious Diseases M7641, Rigshospitalet, Tagensvej 20, 2200 Copenhagen N, Denmark. Phone: 45 35 45 73 75. Fax: 45 35 45 76 44. E-mail: tscmp{at}rh.dk.

Editor: J. M. Mansfield

Infection and Immunity, July 2003, p. 4193-4196, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4193-4196.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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