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Infection and Immunity, July 2003, p. 4197-4200, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4197-4200.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Deletion of a Vibrio cholerae ClC Channel Results in Acid Sensitivity and Enhanced Intestinal Colonization

Yanpeng Ding and Matthew K. Waldor*

Division of Geographic Medicine and Infectious Diseases, Tufts-New England Medical Center and Howard Hughes Medical Institute, Boston, Massachusetts 02111

Received 13 January 2003/ Returned for modification 5 March 2003/ Accepted 3 April 2003

ClC chloride channels are found in all three kingdoms of life though little is known about their functions in prokaryotes. Here we investigated the role of a Vibrio cholerae ClC channel in acid resistance and intestinal colonization. The putative V. cholerae ClC channel was found to confer mild resistance to acid when pH was adjusted with HCl, but not with other acids. Surprisingly, a ClC channel deletion mutant exhibited enhanced intestinal colonization in infant mice.

* Corresponding author. Mailing address: Division of Geographic Medicine and Infectious Diseases, Tufts-New England Medical Center and Howard Hughes Medical Institute, 750 Washington St., Boston, MA 02111. Phone: (617) 636-7618. Fax: (617) 636-5292. E-mail: mwaldor{at}tufts-nemc.org.

Editor: V. J. DiRita

Infection and Immunity, July 2003, p. 4197-4200, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4197-4200.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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