This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, S.
Right arrow Articles by Bäumler, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, S.
Right arrow Articles by Bäumler, A. J.

 Previous Article  |  Next Article 

Infection and Immunity, August 2003, p. 4795-4803, Vol. 71, No. 8
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.8.4795-4803.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Secreted Effector Proteins of Salmonella enterica Serotype Typhimurium Elicit Host-Specific Chemokine Profiles in Animal Models of Typhoid Fever and Enterocolitis

Shuping Zhang,1,{dagger} L. Garry Adams,1 Jairo Nunes,1 Sangeeta Khare,1 Renée M. Tsolis,2 and Andreas J. Bäumler2*

Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4467,1 Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University System Health Science Center, College Station, Texas 77843-11142

Received 7 March 2003/ Returned for modification 28 March 2003/ Accepted 5 May 2003

Infection of bovine ligated loops with the Salmonella enterica serotype Typhimurium wild type but not a sipA sopABDE2 mutant resulted in fluid accumulation, polymorphonuclear cell infiltration, and expression of CXC chemokines, particularly GRO{alpha}. None of these sipA sopABDE2-dependent responses was observed in murine-ligated loops. The majority of GRO{alpha} transcripts localized to bovine intestinal epithelium. Thus, different disease outcomes between mice (i.e., no diarrhea) and calves (i.e., diarrhea) may be due to differences in sipA sopABDE2-dependent CXC chemokine gene expression in epithelial cells.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University System Health Science Center, 407 Reynolds Medical Building, 1114 TAMU, College Station, TX 77843-1114. Phone: (979) 862-7756. Fax: (979) 845-3479. E-mail: abaumler{at}tamu.edu.

Editor: F. C. Fang

{dagger} Present address: Mississippi Veterinary Diagnostic and Research Laboratory, Department of Veterinary Pathobiology/Population Medicine, College of Veterinary Medicine, Mississippi State University, Jackson, MS 39296.

Infection and Immunity, August 2003, p. 4795-4803, Vol. 71, No. 8
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.8.4795-4803.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Winter, S. E., Thiennimitr, P., Nuccio, S.-P., Haneda, T., Winter, M. G., Wilson, R. P., Russell, J. M., Henry, T., Tran, Q. T., Lawhon, S. D., Gomez, G., Bevins, C. L., Russmann, H., Monack, D. M., Adams, L. G., Baumler, A. J. (2009). Contribution of Flagellin Pattern Recognition to Intestinal Inflammation during Salmonella enterica Serotype Typhimurium Infection. Infect. Immun. 77: 1904-1916 [Abstract] [Full Text]  
  • Hapfelmeier, S., Muller, A. J., Stecher, B., Kaiser, P., Barthel, M., Endt, K., Eberhard, M., Robbiani, R., Jacobi, C. A., Heikenwalder, M., Kirschning, C., Jung, S., Stallmach, T., Kremer, M., Hardt, W.-D. (2008). Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent stepin {Delta}invG S. Typhimurium colitis. JEM 205: 437-450 [Abstract] [Full Text]  
  • Raffatellu, M., Santos, R. L., Chessa, D., Wilson, R. P., Winter, S. E., Rossetti, C. A., Lawhon, S. D., Chu, H., Lau, T., Bevins, C. L., Adams, L. G., Baumler, A. J. (2007). The Capsule Encoding the viaB Locus Reduces Interleukin-17 Expression and Mucosal Innate Responses in the Bovine Intestinal Mucosa during Infection with Salmonella enterica Serotype Typhi. Infect. Immun. 75: 4342-4350 [Abstract] [Full Text]  
  • Rodenburg, W., Bovee-Oudenhoven, I. M. J., Kramer, E., van der Meer, R., Keijer, J. (2007). Gene expression response of the rat small intestine following oral Salmonella infection. Physiol. Genomics 30: 123-133 [Abstract] [Full Text]  
  • Giacomodonato, M. N., Uzzau, S., Bacciu, D., Caccuri, R., Sarnacki, S. H., Rubino, S., Cerquetti, M. C. (2007). SipA, SopA, SopB, SopD and SopE2 effector proteins of Salmonella enterica serovar Typhimurium are synthesized at late stages of infection in mice. Microbiology 153: 1221-1228 [Abstract] [Full Text]  
  • Dvorak, C. M. T., Hirsch, G. N., Hyland, K. A., Hendrickson, J. A., Thompson, B. S., Rutherford, M. S., Murtaugh, M. P. (2006). Genomic dissection of mucosal immunobiology in the porcine small intestine. Physiol. Genomics 28: 5-14 [Abstract] [Full Text]  
  • Raffatellu, M., Chessa, D., Wilson, R. P., Tukel, C., Akcelik, M., Baumler, A. J. (2006). Capsule-Mediated Immune Evasion: a New Hypothesis Explaining Aspects of Typhoid Fever Pathogenesis. Infect. Immun. 74: 19-27 [Full Text]  
  • Raffatellu, M., Sun, Y.-H., Wilson, R. P., Tran, Q. T., Chessa, D., Andrews-Polymenis, H. L., Lawhon, S. D., Figueiredo, J. F., Tsolis, R. M., Adams, L. G., Baumler, A. J. (2005). Host Restriction of Salmonella enterica Serotype Typhi Is Not Caused by Functional Alteration of SipA, SopB, or SopD. Infect. Immun. 73: 7817-7826 [Abstract] [Full Text]  
  • DePaolo, R. W., Lathan, R., Rollins, B. J., Karpus, W. J. (2005). The Chemokine CCL2 Is Required for Control of Murine Gastric Salmonella enterica Infection. Infect. Immun. 73: 6514-6522 [Abstract] [Full Text]  
  • Stecher, B., Macpherson, A. J., Hapfelmeier, S., Kremer, M., Stallmach, T., Hardt, W.-D. (2005). Comparison of Salmonella enterica Serovar Typhimurium Colitis in Germfree Mice and Mice Pretreated with Streptomycin. Infect. Immun. 73: 3228-3241 [Abstract] [Full Text]  
  • Raffatellu, M., Chessa, D., Wilson, R. P., Dusold, R., Rubino, S., Baumler, A. J. (2005). The Vi Capsular Antigen of Salmonella enterica Serotype Typhi Reduces Toll-Like Receptor-Dependent Interleukin-8 Expression in the Intestinal Mucosa. Infect. Immun. 73: 3367-3374 [Abstract] [Full Text]  
  • Smith, C. K., Kaiser, P., Rothwell, L., Humphrey, T., Barrow, P. A., Jones, M. A. (2005). Campylobacter jejuni-Induced Cytokine Responses in Avian Cells. Infect. Immun. 73: 2094-2100 [Abstract] [Full Text]  
  • Knodler, L. A., Finlay, B. B., Steele-Mortimer, O. (2005). The Salmonella Effector Protein SopB Protects Epithelial Cells from Apoptosis by Sustained Activation of Akt. J. Biol. Chem. 280: 9058-9064 [Abstract] [Full Text]  
  • Raffatellu, M., Wilson, R. P., Chessa, D., Andrews-Polymenis, H., Tran, Q. T., Lawhon, S., Khare, S., Adams, L. G., Baumler, A. J. (2005). SipA, SopA, SopB, SopD, and SopE2 Contribute to Salmonella enterica Serotype Typhimurium Invasion of Epithelial Cells. Infect. Immun. 73: 146-154 [Abstract] [Full Text]  
  • Stecher, B., Hapfelmeier, S., Muller, C., Kremer, M., Stallmach, T., Hardt, W.-D. (2004). Flagella and Chemotaxis Are Required for Efficient Induction of Salmonella enterica Serovar Typhimurium Colitis in Streptomycin-Pretreated Mice. Infect. Immun. 72: 4138-4150 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»