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Infection and Immunity, August 2003, p. 4815-4817, Vol. 71, No. 8
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.8.4815-4817.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Major Histocompatibility Complex-Dependent Susceptibility to Cryptococcus neoformans in Mice

Erin E. McClelland,1* Donald L. Granger,2 and Wayne K. Potts1

Biology Department, University of Utah, Salt Lake City, Utah 84112, and,1 Division of Infectious Diseases, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah 841322

Received 10 March 2003/ Returned for modification 21 April 2003/ Accepted 3 May 2003

To evaluate the role of major histocompatibility complex (MHC) genes in the resistance to Cryptococcus neoformans, we conducted infection experiments in MHC-congenic strains of mice. Significant MHC-dependent susceptibility differences were found among homozygotes and heterozygotes. This study is the first experimental demonstration of MHC-dependent susceptibility to C. neoformans infections in mice and indicates that MHC genes can be important in host resistance.

* Corresponding author. Mailing address: 257 South 1400 East, Salt Lake City, UT 84112. Phone: (801) 585-9678. Fax: (801) 581-4668. E-mail: Erin.McClelland{at}m.cc.utah.edu.

Editor: T. R. Kozel

Infection and Immunity, August 2003, p. 4815-4817, Vol. 71, No. 8
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.8.4815-4817.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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