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Infection and Immunity, August 2003, p. 4823-4827, Vol. 71, No. 8
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.8.4823-4827.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Cell Surface Antigens of Mycoplasma Species Bovine Group 7 Bind to and Activate Plasminogen.

Kylie Bower,1,2 Steven P. Djordjevic,2* Nicholas M. Andronicos,1 and Marie Ranson1

Department of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522,1 NSW Agriculture, Elizabeth Macarthur Agricultural Institute, Camden, New South Wales 2570, Australia2

Received 28 October 2002/ Returned for modification 11 February 2003/ Accepted 15 May 2003

Mycoplasma species bovine group 7 bound plasminogen at the cell surface in a lysine-dependent manner. Cell-bound plasminogen was rapidly activated to plasmin by exogenous urokinase, and this activity was associated with plasminogen binding capacity. Binding assays using plasminogen modified with a trifunctional cross-linking agent revealed several binding proteins.

* Corresponding author. Mailing address: NSW Agriculture, Elizabeth Macarthur Agricultural Institute, Private Mail Bag 8, Camden, NSW 2570, Australia. Phone: 61-246-406426. Fax: 61-246-406384. E-mail: steve.djordjevic{at}agric.nsw.gov.au.

Editor: S. H. E. Kaufmann

Infection and Immunity, August 2003, p. 4823-4827, Vol. 71, No. 8
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.8.4823-4827.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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