Retraction for Marcato et al., Infect. Immun. 70 (3) 1279-1286.
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 Previous Article

Infection and Immunity, August 2003, p. 4828, Vol. 71, No. 8
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.8.4828.2003

RETRACTION

Cloned Shiga Toxin 2 B Subunit Induces Apoptosis in Ramos Burkitt's Lymphoma B Cells

Paola Marcato, George Mulvey, and Glen D. Armstrong

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada

Volume 70, no. 3, p. 1279-1286, 2002. Subsequent to the publication of this article, we discovered that additional preparations of cloned Shiga toxin 2 (Stx2) B subunit lacked apoptogenic activity in Ramos Burkitt's lymphoma B cells. After exhaustive biological and biochemical characterization, we discovered that the Stx2 B subunit preparations used in our study contained previously undetected Stx2 holotoxin. Since this contaminating Stx2 holotoxin was likely responsible for the apoptogenic activity we attributed to the Stx2 B subunit in this article, we retract the conclusion that the Stx2 B subunit, absent any A subunit activity, initiated apoptosis in Ramos cells. This new finding does not alter our conclusions related to the lack of apoptogenic activity in the Stx1 B subunit preparation or the protective effect of Z-VAD-fmk on protein biosynthesis in the Stx2 B subunit-treated Ramos cells.

Infection and Immunity, August 2003, p. 4828, Vol. 71, No. 8
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.8.4828.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Marcato, P., Griener, T. P., Mulvey, G. L., Armstrong, G. D. (2005). Recombinant Shiga Toxin B-Subunit-Keyhole Limpet Hemocyanin Conjugate Vaccine Protects Mice from Shigatoxemia. Infect. Immun. 73: 6523-6529 [Abstract] [Full Text]  

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