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Infection and Immunity, September 2003, p. 5355-5359, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5355-5359.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Tumor Necrosis Factor Alpha Is a Key Mediator of Gut Inflammation Seen in Amebic Colitis in Human Intestine in the SCID Mouse-Human Intestinal Xenograft Model of Disease

Departments of Medicine,¹ Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri²

Received 24 January 2003/ Returned for modification 21 February 2003/ Accepted 6 June 2003

We used Entamoeba histolytica infection in human intestinal xenografts to study the roles interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-) in the pathogenesis of amebic colitis. We found that blockade of TNF- reduced inflammation and intestinal damage in amebic infection, while inhibition of IL-1 reduced cytokine production but had less marked effects on inflammation and disease.

Editor: W. A. Petri, Jr.

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