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Infection and Immunity, September 2003, p. 5386-5388, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5386-5388.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Role of Periplasmic Peptidylprolyl Isomerases in Salmonella enterica Serovar Typhimurium Virulence

Sue Humphreys,1 Gary Rowley,1 Andrew Stevenson,1 William J. Kenyon,2 Michael P. Spector,2 and Mark Roberts1*

Molecular Bacteriology Group, Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Glasgow G61 1QH, United Kingdom,1 Department of Biomedical Sciences, University of South Alabama, Mobile, Alabama 366882

Received 21 February 2003/ Returned for modification 1 April 2003/ Accepted 5 June 2003

FkpA is a peptidylprolyl isomerase whose expression is regulated by the alternative sigma factor, sigma factor E ({sigma}E). In contrast to the results of a previous report, inactivation of fkpA was found to have only a minor effect on the ability of Salmonella enterica serovar Typhimurium to invade and survive within epithelial and macrophage cell lines and cause infection in mice. However, an effect of the fkpA mutation on serovar Typhimurium virulence was seen if the mutation was combined with mutations in surA or htrA, two other {sigma}E-regulated genes, which encode proteins involved in protein folding and/or degradation in the periplasm.

* Corresponding author. Mailing address: Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, United Kingdom. Phone: 0141 330 5780. Fax: 0141 330 5602. E-mail: m.roberts{at}vet.gla.ac.uk.

Editor: B. B. Finlay

Infection and Immunity, September 2003, p. 5386-5388, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5386-5388.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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