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Infection and Immunity, September 2003, p. 5394-5397, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5394-5397.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Differential Interleukin-8 and Nitric Oxide Production in Epithelial Cells Induced by Mucosally Invasive and Noninvasive Trypanosoma cruzi Trypomastigotes

C. S. Eickhoff,1 L. Eckmann,2 and D. F. Hoft1*

Department of Internal Medicine, Saint Louis University Health Sciences Center, St. Louis, Missouri,1 Department of Medicine, University of California at San Diego, La Jolla, California2

Received 20 March 2003/ Returned for modification 20 May 2003/ Accepted 20 June 2003

Trypanosoma cruzi metacyclic trypomastigotes (MT), but not blood form trypomastigotes (BFT), are highly mucosally infective. We investigated the abilities of MT and BFT to induce inflammation and/or intracellular killing activity within mucosal epithelia. BFT, but not MT, induced marked increases in interleukin-8, GRO-{alpha}, MCP-1, and nitric oxide production in HeLa and AGS cells, despite similar infectivities. MT may avoid induction of inflammation as an important biological mechanism facilitating mucosal invasion.

* Corresponding author. Mailing address: Division of Infectious Diseases and Immunology, Saint Louis University Health Sciences Center, 3635 Vista Ave., St. Louis, MO 63110. Phone: (314) 577-8648. Fax: (314) 771-3816. E-mail: hoftdf{at}slu.edu.

Editor: J. M. Mansfield

Infection and Immunity, September 2003, p. 5394-5397, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5394-5397.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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