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Infection and Immunity, September 2003, p. 5407-5411, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5407-5411.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Long-Term Protective Immune Response Elicited by Vaccination with an Expression Genomic Library of Toxoplasma gondii

Alberto Fachado,1,2 Alexandro Rodriguez,2 Judith Molina,3 Jaline C. Silvério,1 Ana P. M. P. Marino,1 Luzia M. O. Pinto,1 Sergio O. Angel,4 Juan F. Infante,5 Yara Traub-Cseko,6 Regina R. Amendoeira,7 and Joseli Lannes-Vieira1*

Laboratory of Autoimmunity and Immunoregulation, Department of Immunology,1 Department of Ultra-Structure and Cellular Biology,3 Department of Biochemistry and Molecular Biology,6 Department of Protozoology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil,7 Laboratory of Molecular Biology, Department of Immunology, "Victoria de Giron" Medicine Institute,2 Department of Molecular Biology, "Carlos J. Finaly" Insitute, Havana, Cuba,5 Laboratory of Molecular Biology, Department of Parasitology, "Carlos G. Malbran" Institute, Buenos Aires, Argentina4

Received 30 September 2002/ Returned for modification 10 February 2003/ Accepted 26 May 2003

Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti-T. gondii DNA vaccine.

* Corresponding author: Mailing address: Department of Immunology, Oswaldo Cruz Institute, Fiocruz, Av. Brasil 4365, Rio de Janeiro 21045-900, Brazil. Phone: 55-21-3865-8202. Fax: 55-21-2290-0479. E-mail: lannes{at}ioc.fiocruz.br.

Editor: S. H. E. Kaufmann

Infection and Immunity, September 2003, p. 5407-5411, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5407-5411.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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