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Infection and Immunity, September 2003, p. 5418-5421, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5418-5421.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Signaling via Toll-Like Receptor 5 Can Initiate Inflammatory Mediator Production by Murine Osteoblasts

Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223

Received 16 April 2003/ Returned for modification 6 June 2003/ Accepted 16 June 2003

Murine osteoblasts express Toll-like receptor 5 (TLR5), and this expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Importantly, flagellin activates transcriptional regulators and elicits proinflammatory cytokine production, suggesting TLR5 functionality. TLR5 may represent an important mechanism underlying the recognition of bacterial pathogens by osteoblasts during bone infections.

Editor: J. T. Barbieri

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