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Infection and Immunity, October 2004, p. 6139-6141, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6139-6141.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Granuloma Necrosis during Mycobacterium avium Infection Does Not Require Tumor Necrosis Factor

Manuela Flórido1 and Rui Appelberg1,2*

Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology,1 Instituto de Ciências Biomédicas de Abel Salazar, University of Porto, Porto, Portugal2

Received 27 April 2004/ Returned for modification 10 June 2004/ Accepted 30 June 2004

The infection of tumor necrosis factor (TNF)-deficient mice with low doses of the virulent Mycobacterium avium strain 25291 led to the appearance of necrotic granulomas at 93 days of infection, i.e., sooner than necrotic granulomas appeared in C57BL/6 animals. Additionally, TNF-deficient mice exhibited higher mycobacterial loads in the infected organs, had extremely exacerbated gamma interferon responses as evaluated in the sera of infected animals, and showed reduced survival. Thus, TNF is not required for granuloma necrosis.

* Corresponding author. Mailing address: Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, Rua do Campo Alegre 823, 4150-180 Porto, Portugal. Phone: 351.226074952. Fax: 351.226099157. E-mail: rappelb{at}ibmc.up.pt.

Editor: V. J. DiRita

Infection and Immunity, October 2004, p. 6139-6141, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6139-6141.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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