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Infection and Immunity, October 2004, p. 6151-6156, Vol. 72, No. 10
0019-9567/04/$08.00+0 DOI: 10.1128/IAI.72.10.6151-6156.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
Anne-Marie Gilles,2,4,
and Chantal Le Bouguénec1*
Unité de Pathogénie Bactérienne des Muqueuses,1 Unité de Génétique des Génomes Bactériens,2 Laboratoire de Chimie Structurale des Macromolécules, Institut Pasteur,4 Laboratoire de Neurobiologie et Diversité Cellulaire, ESPCI, Paris, France3
Received 20 April 2004/ Returned for modification 24 May 2004/ Accepted 3 July 2004
We showed that the deoK operon, which confers the ability to use deoxyribose as a carbon source, is more common among pathogenic than commensal Escherichia coli strains. The expression of the deoK operon increases the competitiveness of clinical isolates, suggesting that this biochemical characteristic plays a role in host infectivity.
Present address: Laboratorio Especial de Microbiologia, Instituto Butatan, 05503-900 Sao Paulo, SP, Brazil.
Present address: Unité de Génétique des Génomes Bactériens, Institut Pasteur, Paris, France.
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