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Infection and Immunity, October 2004, p. 6176-6180, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6176-6180.2003
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Limited Role for Interleukin-18 in the Host Protection Response to Pulmonary Infection with Pseudomonas aeruginosa in Mice

Chikara Nakasone,1 Kazuyoshi Kawakami,1* Tomoaki Hoshino,2 Yusuke Kawase,3 Koichi Yokota,3 Kohichiro Yoshino,3 Kiyoshi Takeda,4,{dagger} Shizuo Akira,4 and Atsushi Saito1

Department of Internal Medicine, Division of Infectious Diseases, Graduate School and Faculty of Medicine, University of the Ryukyus, Okinawa,1 The First Department of Internal Medicine, Kurume University, Kurume,2 R&D Laboratories, Nippon Organon K. K.,3 Department of Host Defense, Research Institute for MIcrobial Diseases, Osaka University, Osaka, Japan4

Received 27 April 2004/ Returned for modification 4 June 2004/ Accepted 22 June 2004

We report that clearance of Pseudomonas aeruginosa, accumulation of neutrophils, and synthesis of tumor necrosis factor alpha and macrophage inflammatory protein 2 in the infected lung were not largely different in interleukin-18 (IL-18) knockout or transgenic mice compared with control mice. Our results suggest a limited role for IL-18 in the host defense against P. aeruginosa.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Internal Medicine, Graduate School and Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan. Phone: 81 (98) 895-1144. Fax: 81 (98) 895-1414. E-mail: kawakami{at}med.u-ryukyu.ac.jp.

Editor: J. T. Barbieri

{dagger} Present address: Division of Embryonic and Genetic Engineering, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.

Infection and Immunity, October 2004, p. 6176-6180, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6176-6180.2003
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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