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Infection and Immunity, October 2004, p. 6176-6180, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6176-6180.2003
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Limited Role for Interleukin-18 in the Host Protection Response to Pulmonary Infection with Pseudomonas aeruginosa in Mice

Chikara Nakasone,¹ Kazuyoshi Kawakami,^1* Tomoaki Hoshino,² Yusuke Kawase,³ Koichi Yokota,³ Kohichiro Yoshino,³ Kiyoshi Takeda,^4, Shizuo Akira,⁴ and Atsushi Saito¹

Department of Internal Medicine, Division of Infectious Diseases, Graduate School and Faculty of Medicine, University of the Ryukyus, Okinawa,¹ The First Department of Internal Medicine, Kurume University, Kurume,² R&D Laboratories, Nippon Organon K. K.,³ Department of Host Defense, Research Institute for MIcrobial Diseases, Osaka University, Osaka, Japan⁴

Received 27 April 2004/ Returned for modification 4 June 2004/ Accepted 22 June 2004

We report that clearance of Pseudomonas aeruginosa, accumulation of neutrophils, and synthesis of tumor necrosis factor alpha and macrophage inflammatory protein 2 in the infected lung were not largely different in interleukin-18 (IL-18) knockout or transgenic mice compared with control mice. Our results suggest a limited role for IL-18 in the host defense against P. aeruginosa.

Editor: J. T. Barbieri

Present address: Division of Embryonic and Genetic Engineering, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.

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