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Infection and Immunity, November 2004, p. 6680-6684, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6680-6684.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Shiga Toxin Binding to Isolated Porcine Tissues and Peripheral Blood Leukocytes

Kellie R. K. Winter,1 William C. Stoffregen,2 and Evelyn A. Dean-Nystrom3*

Department of Veterinary Microbiology and Preventive Medicine, Iowa State University,1 Bacterial Diseases of Livestock,2 Pre-Harvest Food Safety and Enteric Diseases Research Units, National Animal Disease Center, USDA Agricultural Research Service, Ames, Iowa3

Received 19 April 2004/ Returned for modification 26 May 2004/ Accepted 23 July 2004

Shiga toxin (Stx) binding sites in porcine tissues and leukocytes were identified by the use of Stx overlay and anti-CD77/Gb3 immunoassays. Stx1 and Stx2 bound to similar tissue locations and leukocytes, although some differences were noted. Previously unreported Stx binding sites were identified in kidney tubules, intestinal lymphoid aggregates, sinusoidal liver cells, alveolar macrophages, and peripheral blood leukocytes.

* Corresponding author. Mailing address: USDA, ARS, National Animal Disease Center, P.O. Box 70, Ames, IA 50010-0070. Phone: (515) 663-7376. Fax: (515) 663-7458. E-mail: enystrom{at}nadc.ars.usda.gov.

Editor: J. D. Clements

Infection and Immunity, November 2004, p. 6680-6684, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6680-6684.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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