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Infection and Immunity, November 2004, p. 6689-6693, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6689-6693.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Moraxella catarrhalis Coaggregates with Streptococcus pyogenes and Modulates Interactions of S. pyogenes with Human Epithelial Cells

Eric R. Lafontaine,1 David Wall,1 Serena L. Vanlerberg,1 Haig Donabedian,2 and Darren D. Sledjeski1*

Department of Medical Microbiology and Immunology,1 Department of Medicine, Medical College of Ohio, Toledo, Ohio2

Received 27 April 2004/ Returned for modification 10 June 2004/ Accepted 27 July 2004

The pathogens Streptococcus pyogenes and Moraxella catarrhalis colonize overlapping regions of the human nasopharynx. We have found that M. catarrhalis can dramatically increase S. pyogenes adherence to human epithelial cells and that species-specific coaggregation of these bacteria correlates with this enhanced adherence.


* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, Medical College of Ohio, Health Education Building, 3055 Arlington Ave., Toledo, OH 43614-5806. Phone: (419) 383-5192. Fax: (419) 383-3002. E-mail: dsledjeski{at}mco.edu.

Editor: D. L. Burns


Infection and Immunity, November 2004, p. 6689-6693, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6689-6693.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.




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