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Infection and Immunity, November 2004, p. 6699-6701, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6699-6701.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Cleavage of the N-Linked Oligosaccharide from the Surfaces of Chlamydia Species Affects Attachment and Infectivity of the Organisms in Human Epithelial and Endothelial Cells

Cho-chou Kuo,* Amy Lee, and Lee Ann Campbell

Department of Pathobiology, University of Washington, Seattle, Washington

Received 14 June 2004/ Returned for modification 19 July 2004/ Accepted 1 August 2004

Previous studies demonstrated that the high-mannose oligosaccharide N linked to the Chlamydia major outer membrane protein inhibited the attachment and infectivity of the organism. The present study showed that cleavage of the glycan with N-glycanase decreased the attachment and infectivity of chlamydial organisms in human epithelial and endothelial cells.

* Corresponding author. Mailing address: Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195. Phone: (206) 543-8689. Fax: (206) 543-3873. E-mail: cckuo{at}u.washington.edu.

Editor: J. T. Barbieri

Infection and Immunity, November 2004, p. 6699-6701, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6699-6701.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Campbell, L. A., Lee, A., Kuo, C.-c. (2006). Cleavage of the N-linked oligosaccharide from the surfaces of Chlamydia species affects infectivity in the mouse model of lung infection.. Infect. Immun. 74: 3027-3029 [Abstract] [Full Text]  


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