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Infection and Immunity, November 2004, p. 6743-6747, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6743-6747.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Identification of Neisseria meningitidis Genetic Loci Involved in the Modulation of Phase Variation Frequencies

Heather L. Alexander,* Andrew W. Rasmussen, and Igor Stojiljkovic

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia

Received 8 February 2004/ Returned for modification 21 April 2004/ Accepted 4 August 2004

It has been proposed that increased phase variation frequencies in Neisseria meningitidis augment transmissibility and invasiveness. A Himar1 mariner transposon mutant library was constructed in serogroup A N. meningitidis and screened for clones with increased phase variation frequencies. Insertions increasing the frequency of slippage events within mononucleotide repeat tracts were identified in three known phase variation-modulating genes (mutS, mutL, and uvrD), as well as six additional loci (pilP, fbpA, fbpB, NMA1233, and two intergenic regions). The implications of these insertion mutations are discussed.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Rd., Atlanta, GA 30322. Phone: (404) 727-5968. Fax: (404) 727-3659. E-mail: heather.alexander{at}hhs.gov.

Editor: J. N. Weiser

Infection and Immunity, November 2004, p. 6743-6747, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6743-6747.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rasmussen, A. W., Alexander, H. L., Perkins-Balding, D., Shafer, W. M., Stojiljkovic, I. (2005). Resistance of Neisseria meningitidis to the Toxic Effects of Heme Iron and Other Hydrophobic Agents Requires Expression of ght. J. Bacteriol. 187: 5214-5223 [Abstract] [Full Text]  


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