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Infection and Immunity, December 2004, p. 7352-7356, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7352-7356.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Cytokine and Fibrogenic Gene Expression in the Conjunctivas of Subjects from a Gambian Community Where Trachoma Is Endemic

Matthew J. Burton,1,2* Robin L. Bailey,1,2 David Jeffries,2 David C. W. Mabey,1 and Martin J. Holland1,2

London School of Hygiene and Tropical Medicine, London, United Kingdom,1 Medical Research Council Laboratories, Fajara, The Gambia2

Received 13 May 2004/ Returned for modification 30 June 2004/ Accepted 21 August 2004

The role of immunity in blinding trachoma is unclear. Conjunctival gene expression was measured in a population where trachoma is endemic. Proinflammatory (tumor necrosis factor alpha and interleukin-1ß [IL-1ß]), anti-inflammatory (IL-10), and fibrogenic (matrix metalloprotease 9) gene expression was increased in active trachoma. Markers indicative of T-cell response (gamma interferon, IL-4, IL-12p40, and perforin) were increased when chlamydial infection was present.

* Corresponding author. Mailing address: International Centre for Eye Health, London School of Hygiene and Tropical Medicine, Keppel St., London WC1E 7HT, United Kingdom. Phone: 44 (0)20 7958 8359. Fax: 44 (0)20 7958 8317. E-mail: matthew.burton{at}lshtm.ac.uk.

Editor: J. T. Barbieri

Infection and Immunity, December 2004, p. 7352-7356, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7352-7356.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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