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Infection and Immunity, December 2004, p. 7357-7359, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7357-7359.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Effect of Inactivation of the HtrA-Like Serine Protease DegQ on the Virulence of Salmonella enterica Serovar Typhimurium in Mice

Jacinta Farn{dagger} and Mark Roberts*

Molecular Bacteriology Group, Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Glasgow, United Kingdom

Received 10 June 2004/ Returned for modification 13 August 2004/ Accepted 19 August 2004

DegQ is a serine protease that is highly homologous to HtrA, an important virulence determinant of Salmonella enterica serovar Typhimurium. We examined if DegQ is involved in serovar Typhimurium pathogenesis. A serovar Typhimurium degQ mutant was as virulent as the wild-type strain in mice. However, a serovar Typhimurium htrA degQ mutant survived less well in murine organs, particularly in the liver, than a serovar Typhimurium htrA mutant. DegQ is not essential for serovar Typhimurium pathogenesis but may play a small role during salmonella growth at systemic sites.

* Corresponding author. Mailing address: Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Rd., Glasgow G61 1QH, United Kingdom. Phone: 141 330 5780. Fax: 141 330 5602. E-mail: m.roberts{at}vet.gla.ac.uk.

Editor: J. T. Barbieri

{dagger} Present address: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia 3052.

Infection and Immunity, December 2004, p. 7357-7359, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7357-7359.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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