This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Munson, R. S.
Right arrow Articles by Mulks, M. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Munson, R. S., Jr.
Right arrow Articles by Mulks, M. H.

 Previous Article  |  Next Article 

Infection and Immunity, February 2004, p. 1143-1146, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1143-1146.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Haemophilus ducreyi Strain ATCC 27722 Contains a Genetic Element with Homology to the Vibrio RS1 Element That Can Replicate as a Plasmid and Confer NAD Independence on Haemophilus influenzae

Robert S. Munson Jr.,1* Huachun Zhong,1 Rachna Mungur,1 William C. Ray,1 Robin J. Shea,2 Gregory G. Mahairas,3 and Martha H. Mulks2

Division of Molecular Medicine, Children's Research Institute, and Department of Pediatrics, The Ohio State University, Columbus, Ohio,1 The Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan,2 The Institute for Systems Biology, Seattle, Washington3

Received 30 June 2003/ Returned for modification 30 August 2003/ Accepted 11 November 2003

The nucleotide sequence of pNAD1, a plasmid from Haemophilus ducreyi identified on the basis of its ability to confer NAD independence on Actinobacillus pleuropneumoniae and H. influenzae, has been determined. In addition to containing the nadV gene, the plasmid contains homologues of the rstR and rstA genes, genes encoding repressor and replication proteins, respectively, in the Vibrio CTX{phi} and the Vibrio RS1 element, suggesting a single-stranded bacteriophage origin for pNAD1. Tandem copies of the plasmid are integrated into the H. ducreyi 35000HP genome.

* Corresponding author. Mailing address: Children's Research Institute, Room W502, 700 Children's Dr., Columbus, OH 43205. Phone: (614) 722-2680. Fax: (614) 722-3273. E-mail: munsonr{at}pediatrics.ohio-state.edu.

Editor: V. J. DiRita

Infection and Immunity, February 2004, p. 1143-1146, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1143-1146.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gazzaniga, F., Stebbins, R., Chang, S. Z., McPeek, M. A., Brenner, C. (2009). Microbial NAD Metabolism: Lessons from Comparative Genomics. Microbiol. Mol. Biol. Rev. 73: 529-541 [Abstract] [Full Text]  
  • Challacombe, J. F., Duncan, A. J., Brettin, T. S., Bruce, D., Chertkov, O., Detter, J. C., Han, C. S., Misra, M., Richardson, P., Tapia, R., Thayer, N., Xie, G., Inzana, T. J. (2007). Complete Genome Sequence of Haemophilus somnus (Histophilus somni) Strain 129Pt and Comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd. J. Bacteriol. 189: 1890-1898 [Abstract] [Full Text]  
  • Gerlach, G., Reidl, J. (2006). NAD+ utilization in pasteurellaceae: simplification of a complex pathway.. J. Bacteriol. 188: 6719-6727 [Full Text]  
  • Shen, K., Antalis, P., Gladitz, J., Sayeed, S., Ahmed, A., Yu, S., Hayes, J., Johnson, S., Dice, B., Dopico, R., Keefe, R., Janto, B., Chong, W., Goodwin, J., Wadowsky, R. M., Erdos, G., Post, J. C., Ehrlich, G. D., Hu, F. Z. (2005). Identification, Distribution, and Expression of Novel Genes in 10 Clinical Isolates of Nontypeable Haemophilus influenzae. Infect. Immun. 73: 3479-3491 [Abstract] [Full Text]  
  • Revollo, J. R., Grimm, A. A., Imai, S.-i. (2004). The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells. J. Biol. Chem. 279: 50754-50763 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»