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Infection and Immunity, February 2004, p. 1150-1154, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1150-1154.2004

Type III Secretion: a Virulence Factor Delivery System Essential for the Pathogenicity of Burkholderia mallei

Ricky L. Ulrich and David DeShazer*

Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011

Received 18 July 2003/ Returned for modification 8 September 2003/ Accepted 30 October 2003

By creating mutations in the Burkholderia mallei ATCC 23344 animal pathogen-like type III secretion system (TTSS), this study analyzes the correlation between type III secretion and the pathogenicity of ATCC 23344 in vivo. Mutagenesis demonstrated that a functional TTSS was required for the full pathogenicity of ATCC 23344 in the BALB/c mouse and Syrian hamster models of infection. However, vaccination with each mutant failed to elicit a protective immunity against challenge with wild-type ATCC 23344.

* Corresponding author. Mailing address: Bacteriology Division, USAMRIID, 1425 Porter St., Fort Detrick, Frederick, MD 21702. Phone: (301) 619-4871. Fax: (301) 619-2152. E-mail: David.DeShazer{at}AMEDD.ARMY.MIL.

Editor: V. J. DiRita

Infection and Immunity, February 2004, p. 1150-1154, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1150-1154.2004




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