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Infection and Immunity, February 2004, p. 1169-1173, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1169-1173.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Activated THP-1 Cells: an Attractive Model for the Assessment of Intracellular Growth Rates of Mycobacterium tuberculosis Isolates

S. A. Theus, M. D. Cave, and K. D. Eisenach*

Central Arkansas Veterans Healthcare System, Departments of Pathology, Microbiology-Immunology, and Anatomy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205

Received 30 May 2003/ Returned for modification 13 August 2003/ Accepted 6 November 2003

Capacity of certain Mycobacterium tuberculosis isolates to grow more rapidly in human macrophages may be indicative of increased virulence. Significant differences were observed in intracellular growth of two isolates from sites of tuberculosis transmission, with an outbreak-associated strain growing faster than a strain causing disease in only one person. Activated THP-1 cells are a suitable alternative to peripheral blood monocyte models.

* Corresponding author. Mailing address: Central Arkansas Veterans Healthcare System, Medical Research Services, 151/LR, 4300 W. 7th St., Room GB-126, Little Rock, AR 72205. Phone: (501) 257-4827. Fax: (501) 664-6748. E-mail: eisenachkathleend{at}uams.edu.

Editor: S. H. E. Kaufmann

Infection and Immunity, February 2004, p. 1169-1173, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1169-1173.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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