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Infection and Immunity, February 2004, p. 1192-1194, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1192-1194.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Hydrogen Peroxide-Mediated Killing of Caenorhabditis elegans: a Common Feature of Different Streptococcal Species

Maike Bolm,1* Wouter T. M. Jansen,2 Ralf Schnabel,3 and Gursharan S. Chhatwal1

GBF—German Research Centre for Biotechnology, 38124 Braunschweig,1 Institut für Genetik, TU Braunschweig, 38106 Braunschweig, Germany,3 University Medical Center, 3584 CX Utrecht, The Netherlands2

Received 6 October 2003/ Returned for modification 7 November 2003/ Accepted 10 November 2003

Recently, we reported that Streptococcus pyogenes kills Caenorhabditis elegans by the use of hydrogen peroxide (H2O2). Here we show that diverse streptococcal species cause death of C. elegans larvae in proportion to the level of H2O2 produced. H2O2 may mask the effects of other pathogenicity factors of catalase-negative bacteria in the C. elegans infection model.

* Corresponding author. Mailing address: Department of Microbial Pathogenesis and Vaccine Research, GBF—German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany. Phone: 49-531-6181-466. Fax: 49-531-6181-708. E-mail: mkb{at}gbf.de.

Editor: D. L. Burns

Infection and Immunity, February 2004, p. 1192-1194, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1192-1194.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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