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Infection and Immunity, February 2004, p. 1199-1203, Vol. 72, No. 2
0019-9567/04/$08.00+0 DOI: 10.1128/IAI.72.2.1199-1203.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
Comparison of Campylobacter jejuni Isolates Implicated in Guillain-Barré Syndrome and Strains That Cause Enteritis by a DNA Microarray
Edward E. Leonard II,1,2,
Lucy S. Tompkins,1,2 Stanley Falkow,1 and Irving Nachamkin3*
Department of Microbiology and Immunology,1
Division of Infectious Diseases, Stanford University, Stanford, California 94305,2
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 191043
Received 17 July 2003/
Returned for modification 16 September 2003/
Accepted 14 October 2003
We asked whether Campylobacter jejuni isolated from patients with Guillain-Barré syndrome (GBS) differ from isolates isolated from patients with uncomplicated gastrointestinal infection using DNA microarray analysis. We found that specific GBS genes or regions were not identified, and microarray analysis confirmed significant genomic heterogeneity among the isolates.
* Corresponding author. Mailing address: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Gates Building, 4th Floor, 3400 Spruce St., Philadelphia, PA 19104-4283. Phone: (215) 662-6651. Fax: (215) 662-6655. E-mail:
nachamki{at}mail.med.upenn.edu.
Editor: V. J. DiRita
Present address: Infectious Disease Group, Bellevue, WA 98004.
Infection and Immunity, February 2004, p. 1199-1203, Vol. 72, No. 2
0019-9567/04/$08.00+0 DOI: 10.1128/IAI.72.2.1199-1203.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
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