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Infection and Immunity, March 2004, p. 1812-1816, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1812-1816.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Characterization of Cytolethal Distending Toxin Genes and Expression in Shiga Toxin-Producing Escherichia coli Strains of Non-O157 Serogroups

Martina Bielaszewska,1* Marina Fell,1 Lilo Greune,2 Rita Prager,3 Angelika Fruth,3 Helmut Tschäpe,3 M. Alexander Schmidt,2 and Helge Karch1

Institut für Hygiene, Universitätsklinikum Münster,1 Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung (ZMBE), Universität Münster, 48149 Münster,2 Robert-Koch Institut, Bereich Wernigerode, 38855 Wernigerode, Germany3

Received 29 August 2003/ Returned for modification 7 November 2003/ Accepted 11 December 2003

We identified cytolethal distending toxin and its gene (cdt) in 17 of 340 non-O157 Shiga toxin-producing Escherichia coli (STEC) strains (serotypes O73:H18, O91:H21, O113:H21, and O153:H18), all of which were eae negative. cdt is either chromosomal and homologous to cdt-V (serotypes O73:H18, O91:H21, and O113:H21) or plasmidborne and identical to cdt-III (serotype O153:H18). Among eae-negative STEC, cdt was associated with disease (P = 0.003).

* Corresponding author. Mailing address: Institut für Hygiene, Universitätsklinikum Münster, Robert-Koch Str. 41, 48149 Münster, Germany. Phone: 49-251-8352216. Fax: 49-251-8357175. E-mail: mbiela{at}uni-muenster.de.

Editor: A. D. O'Brien

Infection and Immunity, March 2004, p. 1812-1816, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1812-1816.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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