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Infection and Immunity, March 2004, p. 1820-1823, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1820-1823.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Highly Purified Vitamin B2 Presents a Promising Therapeutic Strategy for Sepsis and Septic Shock

Toshio Toyosawa, Mamoru Suzuki, Kohtarou Kodama,* and Seiichi Araki

Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki 300-2635, Japan

Received 22 July 2003/ Returned for modification 24 September 2003/ Accepted 21 November 2003

Highly purified vitamin B2 (riboflavin 5'-sodium phosphate; purity > 97%) treatment by intravenous infusion at doses above those used clinically to treat vitamin B2 deficiency showed therapeutic effects in mice not only in cases of endotoxin- and exotoxin-induced shock but also in cases of gram-negative and gram-positive bacterial infection even after the toxemia had already begun.

* Corresponding author. Mailing address: Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan. Phone: 81-29-847-5717. Fax: 81-29-847-2037. E-mail: k-kodama{at}hhc.eisai.co.jp.

Editor: F. C. Fang

Infection and Immunity, March 2004, p. 1820-1823, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1820-1823.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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