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Infection and Immunity, April 2004, p. 2395-2399, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2395-2399.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Genetic Control of Natural Resistance of Mouse Macrophages to Coxiella burnetii Infection In Vitro: Macrophages from Restrictive Strains Control Parasitophorous Vacuole Maturation

Dario S. Zamboni*

Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, UNIFESP, São Paulo SP 04023-062, Brazil

Received 28 July 2003/ Returned for modification 14 October 2003/ Accepted 12 December 2003

Macrophages from A/J and BALB/c mice were more susceptible to Coxiella burnetii phase II infection than were those from C57BL/6, C57BL/10, B10.A, C3H/HePas, and Swiss mice. Resistant macrophages effectively controlled the development of large replication vacuoles (LRVs), which accounted for the restriction of bacterial multiplication within the cultures. However, compared to fibroblasts, all macrophages controlled bacterial multiplication within LRVs.

* Present address: Yale University School of Medicine, Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Room 354, 295 Congress Ave., New Haven, CT 06536. Phone: (203) 737-2409. Fax: (203) 737-2630. E-mail: dario.zamboni{at}yale.edu.

Editor: J. T. Barbieri

Infection and Immunity, April 2004, p. 2395-2399, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2395-2399.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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