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Infection and Immunity, April 2004, p. 2412-2415, Vol. 72, No. 4
0019-9567/04/$08.00+0 DOI: 10.1128/IAI.72.4.2412-2415.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
HLA-A2-Restricted CD8+-Cytotoxic-T-Cell Responses to Novel Epitopes in Mycobacterium tuberculosis Superoxide Dismutase, Alanine Dehydrogenase, and Glutamine Synthetase
Yuzhi Dong,1 Sandra Demaria,2 Xuming Sun,1 Fabio R. Santori,2 Bill M. Jesdale,3 Anne S. De Groot,3 William N. Rom,2 and Yuri Bushkin1*
Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103,1
New York University School of Medicine, New York, New York 10016,2
Brown University School of Medicine, Providence, Rhode Island 029123
Received 21 July 2003/
Returned for modification 20 October 2003/
Accepted 16 January 2004
Major histocompatibility complex class I-restricted CD8+ cytotoxic T lymphocytes (CTL) are implicated in protective Th1 immunity to Mycobacterium tuberculosis infection. We report the identification of three novel HLA-A*0201-restricted CTL epitopes within mycobacterial superoxide dismutase (SodA), L-alanine dehydrogenase (AlaDH), and L-glutamine synthetase (GlnS) proteins.
* Corresponding author. Mailing address: Laboratory of Molecular Immunology, Public Health Research Institute, 225 Warren Street, Newark, NJ 07103. Phone: (973) 854-3350. Fax: (973) 854-3101. E-mail:
yuri{at}phri.org.
Editor: S. H. E. Kaufmann
Infection and Immunity, April 2004, p. 2412-2415, Vol. 72, No. 4
0019-9567/04/$08.00+0 DOI: 10.1128/IAI.72.4.2412-2415.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
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