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Infection and Immunity, April 2004, p. 2420-2424, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2420-2424.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Effect of Growth State on Transcription Levels of Genes Encoding Major Secreted Antigens of Mycobacterium tuberculosis in the Mouse Lung

Lanbo Shi,1 Robert North,2 and Maria Laura Gennaro1*

Public Health Research Institute, Newark, New Jersey 07103,1 Trudeau Institute, Saranac Lake, New York 129832

Received 24 September 2003/ Returned for modification 28 November 2003/ Accepted 5 January 2004

Arrest of the multiplication of Mycobacterium tuberculosis caused by expression of adaptive immunity in mouse lung was accompanied by a 10- to 20-fold decrease in levels of mRNAs encoding the secreted Ag85 complex and 38-kDa lipoprotein. esat-6 mRNA levels were high throughout infection. The data imply that multiplying and nonreplicating tubercle bacilli have different antigen compositions.

* Corresponding author. Mailing address: Public Health Research Institute, Rm. W250G, 225 Warren St., Newark, NJ 07103. Phone: (973) 854-3210. Fax: (973) 854-3101. E-mail: gennaro{at}phri.org.

Editor: S. H. E. Kaufmann

Infection and Immunity, April 2004, p. 2420-2424, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2420-2424.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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