This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Echenique, J.
Right arrow Articles by Trombe, M.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Echenique, J.
Right arrow Articles by Trombe, M.-C.

 Previous Article  |  Next Article 

Infection and Immunity, April 2004, p. 2434-2437, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2434-2437.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae

Jose Echenique,1,{dagger} Aras Kadioglu,2 Susana Romao,1 Peter W. Andrew,2 and Marie-Claude Trombe1*

Laboratoire d’Interactions et Signalisation Cellulaire: Relation Hôte-Pathogène, Institut Louis Bugnard, Centre Hospitalo Universitaire de Rangueil, Université Paul Sabatier, 31403 Toulouse Cedex, France,1 Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN, United Kingdom2

Received 11 November 2003/ Returned for modification 11 December 2003/ Accepted 16 January 2004

In the Streptococcus pneumoniae genome, stkP, encoding a membrane-associated serine/threonine kinase, is not redundant (L. Novakova, S. Romao, J. Echenique, P. Branny, and M.-C. Trombe, unpublished results). The data presented here demonstrate that StkP belongs to the signaling network involved in competence triggering in vitro and lung infection and bloodstream invasion in vivo. In competence, functional StkP is required for activation of comCDE upstream of the autoregulated ring orchestrated by the competence-stimulating peptide. This is the first description of positive regulation of comCDE transcription in balance with its repression by CiaRH.

* Corresponding author. Mailing address: IFR31, EA3036, Interactions Cellulaires, Relation Hôte-Pathogène, CHU Rangueil, Université Paul Sabatier, 31403 Toulouse, France. Phone: 33/561322974. Fax 33/561322620. E-mail: Trombe{at}cict.fr.

Editor: A. D. O'Brien

{dagger} Present address: Departmento de Bioquimica Clinica, Facultad de Ciancias Quimicas, Universidad Nacional de Cordoba, Pabellon Argentina, Ciudad Universitaria, CP5000 Cordoba, Argentina.

Infection and Immunity, April 2004, p. 2434-2437, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2434-2437.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Montfort, A., de Badts, B., Douin-Echinard, V., Martin, P. G. P., Iacovoni, J., Nevoit, C., Therville, N., Garcia, V., Bertrand, M.-A., Bessieres, M.-H., Trombe, M.-C., Levade, T., Benoist, H., Segui, B. (2009). FAN Stimulates TNF{alpha}-Induced Gene Expression, Leukocyte Recruitment, and Humoral Response. J. Immunol. 183: 5369-5378 [Abstract] [Full Text]  
  • Nobbs, A. H., Lamont, R. J., Jenkinson, H. F. (2009). Streptococcus Adherence and Colonization. Microbiol. Mol. Biol. Rev. 73: 407-450 [Abstract] [Full Text]  
  • Osaki, M., Arcondeguy, T., Bastide, A., Touriol, C., Prats, H., Trombe, M.-C. (2009). The StkP/PhpP Signaling Couple in Streptococcus pneumoniae: Cellular Organization and Physiological Characterization. J. Bacteriol. 191: 4943-4950 [Abstract] [Full Text]  
  • Debarbouille, M., Dramsi, S., Dussurget, O., Nahori, M.-A., Vaganay, E., Jouvion, G., Cozzone, A., Msadek, T., Duclos, B. (2009). Characterization of a Serine/Threonine Kinase Involved in Virulence of Staphylococcus aureus. J. Bacteriol. 191: 4070-4081 [Abstract] [Full Text]  
  • Zemansky, J., Kline, B. C., Woodward, J. J., Leber, J. H., Marquis, H., Portnoy, D. A. (2009). Development of a mariner-Based Transposon and Identification of Listeria monocytogenes Determinants, Including the Peptidyl-Prolyl Isomerase PrsA2, That Contribute to Its Hemolytic Phenotype. J. Bacteriol. 191: 3950-3964 [Abstract] [Full Text]  
  • Beltramini, A. M., Mukhopadhyay, C. D., Pancholi, V. (2009). Modulation of Cell Wall Structure and Antimicrobial Susceptibility by a Staphylococcus aureus Eukaryote-Like Serine/Threonine Kinase and Phosphatase. Infect. Immun. 77: 1406-1416 [Abstract] [Full Text]  
  • Giefing, C., Meinke, A. L., Hanner, M., Henics, T., Minh, D. B., Gelbmann, D., Lundberg, U., Senn, B. M., Schunn, M., Habel, A., Henriques-Normark, B., Ortqvist, A., Kalin, M., von Gabain, A., Nagy, E. (2008). Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies. JEM 205: 117-131 [Abstract] [Full Text]  
  • Saskova, L., Novakova, L., Basler, M., Branny, P. (2007). Eukaryotic-Type Serine/Threonine Protein Kinase StkP Is a Global Regulator of Gene Expression in Streptococcus pneumoniae. J. Bacteriol. 189: 4168-4179 [Abstract] [Full Text]  
  • Kristich, C. J., Wells, C. L., Dunny, G. M. (2007). A eukaryotic-type Ser/Thr kinase in Enterococcus faecalis mediates antimicrobial resistance and intestinal persistence. Proc. Natl. Acad. Sci. USA 104: 3508-3513 [Abstract] [Full Text]  
  • Jones, G., Dyson, P. (2006). Evolution of Transmembrane Protein Kinases Implicated in Coordinating Remodeling of Gram-Positive Peptidoglycan: Inside versus Outside. J. Bacteriol. 188: 7470-7476 [Abstract] [Full Text]  
  • Hussain, H., Branny, P., Allan, E. (2006). A Eukaryotic-Type Serine/Threonine Protein Kinase Is Required for Biofilm Formation, Genetic Competence, and Acid Resistance in Streptococcus mutans. J. Bacteriol. 188: 1628-1632 [Abstract] [Full Text]  
  • Romao, S., Memmi, G., Oggioni, M. R., Trombe, M.-C. (2006). LuxS impacts on LytA-dependent autolysis and on competence in Streptococcus pneumoniae. Microbiology 152: 333-341 [Abstract] [Full Text]  
  • Sebert, M. E., Patel, K. P., Plotnick, M., Weiser, J. N. (2005). Pneumococcal HtrA Protease Mediates Inhibition of Competence by the CiaRH Two-Component Signaling System. J. Bacteriol. 187: 3969-3979 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»