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Infection and Immunity, May 2004, p. 3042-3047, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3042-3047.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Presence of Pili on the Surface of Francisella tularensis

Horacio Gil, Jorge L. Benach, and David G. Thanassi*

Center for Infectious Diseases, Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794-5120

Received 27 November 2003/ Returned for modification 17 December 2003/ Accepted 30 January 2004

Francisella tularensis is a highly infectious gram-negative bacterium with potential for use as a bioweapon. Analysis of the F. tularensis live vaccine strain (LVS) ultrastructure by electron microscopy revealed the presence of long, thin fibers, similar in appearance to type 4 pili. The highly virulent F. tularensis Schu S4 strain was found to contain type 4 pilus genes, and we confirmed that these genes are present and expressed in the LVS.

* Corresponding author. Mailing address: Center for Infectious Diseases, Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5120. Phone: (631) 632-4549. Fax: (631) 632-4294. E-mail: david.thanassi{at}stonybrook.edu.

Editor: V. J. DiRita

Infection and Immunity, May 2004, p. 3042-3047, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3042-3047.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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