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Infection and Immunity, May 2004, p. 3081-3083, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3081-3083.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Fibrinogen Binding Protein of Staphylococcus epidermidis Is a Target for Opsonic Antibodies

Anna Rennermalm,1 Martin Nilsson,2 and Jan-Ingmar Flock1*

Department of Laboratory Medicine, Division of Clinical Bacteriology, Karolinska Institutet, Stockholm,1 Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden2

Received 19 December 2003/ Returned for modification 22 January 2004/ Accepted 5 February 2004

Antibodies against the fibrinogen binding protein (Fbe) of Staphylococcus epidermidis significantly increased macrophage phagocytosis. Antibodies against autolysin E were opsonic but to a lesser extent. Antibodies against a novel, putatively surface-located antigen were unable to enhance phagocytosis. The severity of systemic infection of mice with S. epidermidis was reduced if the bacteria were preopsonized with anti-Fbe prior to administration. Fbe is thus a strong candidate for protein vaccination against S. epidermidis infection, and antibodies against Fbe can be used to prevent or treat infections caused by S. epidermidis.

* Corresponding author. Mailing address: Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Bacteriology, Huddinge University Hospital, F82, S-141 86 Stockholm, Sweden. Phone: 46 8 5858 1169. Fax: 46 8 711 3918. E-mail: jan-ingmar.flock{at}labmed.ki.se.

Editor: F. C. Fang

Infection and Immunity, May 2004, p. 3081-3083, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3081-3083.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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