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 Previous Article

Infection and Immunity, May 2004, p. 3084-3087, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3084-3087.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Porcine Choroid Plexus Epithelial Cells Induce Streptococcus suis Bacteriostasis In Vitro

Rüdiger A. Adam,1 Tobias Tenenbaum,1 Peter Valentin-Weigand,2 Maurice Laryea,1 Bernd Schwahn,1 Susanne Angelow,3 Hans-Joachim Galla,3 Walter Däubener,4 and Horst Schroten1*

Klinik für Allgemeine Pädiatrie,1 Institut für Medizinische Mikrobiologie, Universitätsklinikum Düsseldorf, Düsseldorf,4 Institut für Mikrobiologie, Zentrum für Infektionsmedizin, Tierärztliche Hochschule Hannover, Hannover,2 Institut für Biochemie der Westfälischen Wilhelms-Universität Münster, Münster, Germany3

Received 30 October 2003/ Returned for modification 10 December 2003/ Accepted 5 February 2004

The involvement of the choroid plexus in host defense during bacterial meningitis is unclear. Aiming to elucidate possible antibacterial mechanisms, we stimulated primary porcine choroid plexus epithelial cells (pCPEC) with proinflammatory cytokines and challenged them with various Streptococcus suis strains. In the supernatant of gamma interferon (IFN-{gamma})-stimulated pCPEC, streptococcal growth was markedly suppressed. Costimulation with tumor necrosis factor alpha enhanced this bacteriostatic effect, while supplementation of L-tryptophan completely eliminated it. We also demonstrate that an activation of indoleamine 2,3-dioxygenase in the pCPEC seems to be responsible for the IFN-{gamma}-induced bacteriostasis. This supports the hypothesis of an active role of the choroid plexus in host defense against bacterial meningitis.

* Corresponding author. Mailing address: Pädiatrische Infektiologie, Klinik für Allgemeine Pädiatrie, Moorenstr. 5, 40225 Düsseldorf, Germany. Phone: 49-211-8117687. Fax: 49-211-8119514. E-mail: schroten{at}uni-duesseldorf.de.

Editor: J. N. Weiser

Infection and Immunity, May 2004, p. 3084-3087, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3084-3087.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Graveline, R., Segura, M., Radzioch, D., Gottschalk, M. (2007). TLR2-dependent recognition of Streptococcus suis is modulated by the presence of capsular polysaccharide which modifies macrophage responsiveness. Int Immunol 19: 375-389 [Abstract] [Full Text]  


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