This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ASM journals
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Martinez, L. R.
Right arrow Articles by Casadevall, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martinez, L. R.
Right arrow Articles by Casadevall, A.

 Previous Article  |  Next Article 

Infection and Immunity, June 2004, p. 3674-3679, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3674-3679.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Antibody to Cryptococcus neoformans Glucuronoxylomannan Inhibits the Release of Capsular Antigen

Luis R. Martinez, Dariush Moussai, and Arturo Casadevall*

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York

Received 15 December 2003/ Returned for modification 13 January 2004/ Accepted 12 February 2004

Cryptococcus neoformans releases capsular polysaccharide in the supernatant of liquid cultures and in tissues. Significantly less glucuronoxylomannan (GXM) was released by C. neoformans in the presence of capsule-binding monoclonal antibody (MAb). MAb-mediated inhibition of GXM release may be another mechanism by which humoral immunity can mediate protection against this pathogen.

* Corresponding author. Mailing address: Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461. Phone: (718) 430-2215. Fax: (718) 430-8968. E-mail: casadeva{at}aecom.yu.edu.

Editor: T. R. Kozel

Infection and Immunity, June 2004, p. 3674-3679, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3674-3679.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Robertson, E. J., Casadevall, A. (2009). Antibody-Mediated Immobilization of Cryptococcus neoformans Promotes Biofilm Formation. Appl. Environ. Microbiol. 75: 2528-2533 [Abstract] [Full Text]  
  • Rachini, A., Pietrella, D., Lupo, P., Torosantucci, A., Chiani, P., Bromuro, C., Proietti, C., Bistoni, F., Cassone, A., Vecchiarelli, A. (2007). An Anti-{beta}-Glucan Monoclonal Antibody Inhibits Growth and Capsule Formation of Cryptococcus neoformans In Vitro and Exerts Therapeutic, Anticryptococcal Activity In Vivo. Infect. Immun. 75: 5085-5094 [Abstract] [Full Text]  
  • Maxson, M. E., Dadachova, E., Casadevall, A., Zaragoza, O. (2007). Radial Mass Density, Charge, and Epitope Distribution in the Cryptococcus neoformans Capsule. Eukaryot Cell 6: 95-109 [Abstract] [Full Text]  
  • Martinez, L. R., Casadevall, A. (2005). Specific Antibody Can Prevent Fungal Biofilm Formation and This Effect Correlates with Protective Efficacy. Infect. Immun. 73: 6350-6362 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»