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Infection and Immunity, August 2004, p. 4874-4877, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4874-4877.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Characterization of Adenylate Cyclase-Hemolysin Gene Duplication in a Bordetella pertussis Isolate

Karine Dalet,1,{dagger} Christian Weber,2,{dagger} Laurent Guillemot,1 Elisabeth Njamkepo,1 and Nicole Guiso1*

Unité Prévention et Thérapie Moléculaires des Maladies Humaines,1 Unité Postulante de Biologie Cellulaire du Parasitisme, Institut Pasteur, 75724 Paris Cedex 15, France2

Received 7 January 2004/ Returned for modification 18 March 2004/ Accepted 24 April 2004

We describe a clinical isolate of Bordetella pertussis, the agent responsible for whooping cough, composed of at least two clones harboring one or two copies of the cya locus encoding one of the major toxins, adenylate cyclase-hemolysin. No difference was observed between the two clones in murine and cellular models, probably due to the high instability of the cya locus duplication.

* Corresponding author. Mailing address: Unité Prévention et Thérapie Moléculaires des Maladies Humaines, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. Phone: (1) 45 68 83 34. Fax: (1) 40 61 35 33. E-mail: nguiso{at}pasteur.fr.

Editor: J. T. Barbieri

{dagger} K.D. and C.W. contributed equally to this work.

Infection and Immunity, August 2004, p. 4874-4877, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4874-4877.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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