This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eberl, M.
Right arrow Articles by Christiansen, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eberl, M.
Right arrow Articles by Christiansen, G.

 Previous Article  |  Next Article 

Infection and Immunity, August 2004, p. 4881-4883, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4881-4883.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Mycoplasma penetrans Is Capable of Activating V{gamma}9/V{delta}2 T Cells While Other Human Pathogenic Mycoplasmas Fail To Do So

Matthias Eberl,1* Martin Hintz,1 Zandraa Jamba,1 Ewald Beck,1 Hassan Jomaa,1 and Gunna Christiansen2

Biochemisches Institut, Justus-Liebig-Universität Giessen, Giessen, Germany,1 Institut for Medicinsk Mikrobiologi og Immunologi, Aarhus Universitet, Århus, Denmark2

Received 20 February 2004/ Returned for modification 5 April 2004/ Accepted 6 May 2004

While most mycoplasma species appear to have evolutionarily lost the ability to synthesize isoprenoid precursors, Mycoplasma penetrans has retained the nonmevalonate pathway that proceeds via the immunogenic intermediate (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Consequently, this pathogen is capable of stimulating human V{gamma}9/V{delta}2 T cells.

* Corresponding author. Mailing address: Biochemisches Institut, Infektiologie, Justus-Liebig-Universität Giessen, Friedrichstrasse 24, 35392 Giessen, Germany. Phone: (49) 641 99 47442. Fax: (49) 641 99 47529. E-mail: matthias.eberl{at}biochemie.med.uni-giessen.de.

Editor: J. D. Clements

Infection and Immunity, August 2004, p. 4881-4883, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4881-4883.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ali, Z., Yan, L., Plagman, N., Reichenberg, A., Hintz, M., Jomaa, H., Villinger, F., Chen, Z. W. (2009). {gamma}{delta} T Cell Immune Manipulation during Chronic Phase of Simian HIV Infection Confers Immunological Benefits. J. Immunol. 183: 5407-5417 [Abstract] [Full Text]  
  • Ali, Z., Shao, L., Halliday, L., Reichenberg, A., Hintz, M., Jomaa, H., Chen, Z. W. (2007). Prolonged (E)-4-Hydroxy-3-Methyl-But-2-Enyl Pyrophosphate-Driven Antimicrobial and Cytotoxic Responses of Pulmonary and Systemic V{gamma}2V{delta}2 T Cells in Macaques. J. Immunol. 179: 8287-8296 [Abstract] [Full Text]  
  • Puan, K.-J., Jin, C., Wang, H., Sarikonda, G., Raker, A. M., Lee, H. K., Samuelson, M. I., Marker-Hermann, E., Pasa-Tolic, L., Nieves, E., Giner, J.-L., Kuzuyama, T., Morita, C. T. (2007). Preferential recognition of a microbial metabolite by human V{gamma}2V{delta}2 T cells. Int Immunol 19: 657-673 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»