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Infection and Immunity, September 2004, p. 5216-5226, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5216-5226.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Gastric Transcription Profile of Helicobacter pylori Infection in the Rhesus Macaque

Jennifer L. Huff,1,2* Lori M. Hansen,1,2 and Jay V. Solnick1,2,3

Departments of Internal Medicine,3 Medical Microbiology and Immunology,1 Center for Comparative Medicine, University of California, Davis, Davis, California2

Received 21 January 2004/ Returned for modification 10 May 2004/ Accepted 15 June 2004

Infection with Helicobacter pylori is usually asymptomatic but sometimes progresses to peptic ulcer disease or gastric adenocarcinoma. The development of disease involves both host and bacterial factors. In order to better understand host factors in pathogenesis, we studied the gastric transcription profile of H. pylori infection in the rhesus macaque by using DNA microarrays. Significant changes were found in the expression of genes important for innate immunity, chemokines and cytokines, cell growth and differentiation, apoptosis, structural proteins, and signal transduction and transcription factors. This broad transcription profile demonstrated expected up-regulation of cell structural elements and the host inflammatory and immune response, as well as the novel finding of down-regulation of heat shock proteins. These results provide a unique view of acute H. pylori infection in a relevant animal model system and will direct future studies regarding the host response to H. pylori infection.

* Corresponding author. Mailing address: Center for Comparative Medicine, University of California, Davis, Davis, CA 95616. Phone: (530) 752-1334. Fax: (530) 752-7914. E-mail: jlmshuff{at}ucdavis.edu.

Editor: V. J. DiRita

Infection and Immunity, September 2004, p. 5216-5226, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5216-5226.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Oshlack, A., Chabot, A. E., Smyth, G. K., Gilad, Y. (2007). Using DNA microarrays to study gene expression in closely related species. Bioinformatics 23: 1235-1242 [Abstract] [Full Text]  
  • Resnick, M B, Sabo, E, Meitner, P A, Kim, S S, Cho, Y, Kim, H K, Tavares, R, Moss, S F (2006). Global analysis of the human gastric epithelial transcriptome altered by Helicobacter pylori eradication in vivo. Gut 55: 1717-1724 [Abstract] [Full Text]  


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