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Infection and Immunity, September 2004, p. 5292-5297, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5292-5297.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Induction of Protection against Porcine Cysticercosis by Vaccination with Recombinant Oncosphere Antigens

Ana Flisser,1,2 Charles G. Gauci,3 André Zoli,4 Joel Martinez-Ocaña,1 Adriana Garza-Rodriguez,1 Jose Luis Dominguez-Alpizar,5 Pablo Maravilla,1 Rossana Rodriguez-Canul,6 Guillermina Avila,2 Laura Aguilar-Vega,2 Craig Kyngdon,3 Stanny Geerts,7 and Marshall W. Lightowlers3*

Direccion de Investigación, Hospital General "Dr. Manuel Gea Gonzalez," SSA,1 Departamento de Microbiologia y Parasitologia, Facultad de Medicina, UNAM, Mexico DF,2 Facultad de Medicina Veterinaria,5 CINVESTAV, Merida, Yucatan, Mexico,6 Veterinary Clinical Centre, The University of Melbourne, Werribee, Victoria, Australia,3 Taeniasis-Cysticercosis Project, Department of Animal Production, Faculty of Agriculture, University of Dschang, Dschang, Cameroon,4 Prins Leopold Instituut voor Tropische Geneeskunde, Antwerp, Belgium7

Received 26 April 2004/ Returned for modification 29 May 2004/ Accepted 3 June 2004

Two recombinant Taenia solium oncosphere antigens, designated TSOL18 and TSOL45-1A, were investigated as vaccines to prevent transmission of the zoonotic disease cysticercosis through pigs. Both antigens were effective in inducing very high levels of protection (up to 100%) in three independent vaccine trials in pigs against experimental challenge infection with T. solium eggs, which were undertaken in Mexico and Cameroon. This is the highest level of protection that has been achieved against T. solium infection in pigs by vaccination with a defined antigen. TSOL18 and TSOL45-1A provide the basis for development of a highly effective practical vaccine that could assist in the control and, potentially, the eradication of human neurocysticercosis.

* Corresponding author. Mailing address: Veterinary Clinical Centre, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia. Phone: 61 3 9731 2284. Fax: 61 3 9741 5461. E-mail: marshall{at}unimelb.edu.au.

Editor: W. A. Petri, Jr.

Infection and Immunity, September 2004, p. 5292-5297, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5292-5297.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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