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Infection and Immunity, September 2004, p. 5470-5474, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5470-5474.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Chlamydia trachomatis Infection Inhibits Both Bax and Bak Activation Induced by Staurosporine

Yangming Xiao, Youmin Zhong, Whitney Greene, Feng Dong, and Guangming Zhong*

Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas

Received 13 March 2004/ Returned for modification 4 May 2004/ Accepted 10 June 2004

We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229. Phone: (210) 567-1169. Fax: (210) 567-0293. E-mail: Zhongg{at}UTHSCSA.EDU.

Editor: F. C. Fang

Infection and Immunity, September 2004, p. 5470-5474, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5470-5474.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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