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Infection and Immunity, September 2004, p. 5498-5501, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5498-5501.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Host Response to a dam Mutant of Salmonella enterica Serovar Enteritidis with a Temperature-Sensitive Phenotype

Mónica N. Giacomodonato,1,2 Sebastián H. Sarnacki,1 Roberto L. Caccuri,2 Daniel O. Sordelli,2 and M. Cristina Cerquetti1,2*

Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET),1 Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina2

Received 20 April 2004/ Returned for modification 17 May 2004/ Accepted 21 May 2004

The temperature-sensitive dam mutant strain of Salmonella enterica serovar Enteritidis SD1 is highly attenuated and induces innate and protective immunity in mice. SD1 activates NF-{kappa}B and induces gamma interferon secretion. Early interaction of the SD1 mutant with intestinal epithelial cells was associated with ruffling of enterocytes. Invading bacteria were found inside Peyer's patches after inoculation.

* Corresponding author. Mailing address: CEFYBO-CONICET, Serrano 669, 1414 Buenos Aires, Argentina. Phone: 54 11 4855 7194. Fax: 54 11 4856 2751. E-mail: ccerquetti{at}yahoo.com.ar.

Editor: F. C. Fang

Infection and Immunity, September 2004, p. 5498-5501, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5498-5501.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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