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Infection and Immunity, January 2005, p. 622-626, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.622-626.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Intercellular Adhesion Molecule 1-Dependent Activation of Interleukin 8 Expression in Candida albicans-Infected Human Gingival Epithelial Cells

Hiroshi Egusa,1,2* Hiroki Nikawa,1 Seicho Makihira,1 Anahid Jewett,3 Hirofumi Yatani,2 and Taizo Hamada1

Department of Prosthetic Dentistry, Hiroshima University Graduate School of Biomedical Sciences, Minami-ku, Hiroshima City,1 Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, Suita City, Osaka, Japan,2 The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, California3

Received 25 August 2004/ Returned for modification 31 August 2004/ Accepted 10 September 2004

Increased induction of interleukin 8 (IL-8) and intercellular adhesion molecule 1 (ICAM-1) by oral epithelial cells may play a role in the host defense mechanism in oropharyngeal candidiasis; however, little is known about the expression feature of these molecules on human gingival epithelial cells (HGECs) during Candida albicans infection. In this report we present evidence that neutralization with antibody against ICAM-1 inhibited both the adherence of C. albicans to HGECs and the Candida-induced production of IL-8, suggesting a role for ICAM-1 in recognition and signaling in HGECs to express IL-8 upon infection with C. albicans.

* Corresponding author. Mailing address: Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita City, Osaka 565-0871, Japan, Phone: 81-6-6879-2946. Fax: 81-6-6879-2947. E-mail: egu{at}dent.osaka-u.ac.jp.

Editor: T. R. Kozel

Infection and Immunity, January 2005, p. 622-626, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.622-626.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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