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Infection and Immunity, January 2005, p. 657-660, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.657-660.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Relative Contributions of Innate and Acquired Host Responses to Bacterial Control and Arthritis Development in Lyme Disease

Xiaohui Wang,1 Ying Ma,1 John H. Weis,1 James F. Zachary,2 Carsten J. Kirschning,3 and Janis J. Weis1*

Department of Pathology, University of Utah, Salt Lake City, Utah,1 Department of Veterinary Pathobiology, University of Illinois, Urbana, Illinois,2 Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany3

Received 14 July 2004/ Returned for modification 25 August 2004/ Accepted 19 September 2004

TLR2–/–/scid double-mutant mice were infected with B. burgdorferi to assess the relative importance of acquired and innate host defenses. Although spirochete levels at 4 weeks were lower in TLR2–/– mice than in TLR2–/–/scid mice, the increased arthritis severity of TLR2 (Toll-like receptor 2)-deficient mice was reduced by the presence of the scid mutation.

* Corresponding author. Mailing address: Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132-2501. Phone: (801) 581-8386. Fax: (801) 581-4517. address: E-mail: Janis.weis{at}path.utah.edu.

Editor: F. C. Fang

Infection and Immunity, January 2005, p. 657-660, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.657-660.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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