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Infection and Immunity, October 2005, p. 6508-6513, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.6508-6513.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Clearance of Bordetella parapertussis from the Lower Respiratory Tract Requires Humoral and Cellular Immunity

Daniel N. Wolfe, Girish S. Kirimanjeswara, and Eric T. Harvill*

Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802

Received 9 May 2005/ Returned for modification 13 June 2005/ Accepted 1 July 2005

Bordetella parapertussis and Bordetella pertussis are closely related species that cause whooping cough, an acute, immunizing disease. Their coexistence in the same host populations at the same time and vaccine studies showing that B. pertussis vaccines have little effect on B. parapertussis infection or disease suggest that the protective immunity induced by each does not efficiently cross protect against the other. Although the mechanisms of protective immunity to B. pertussis have been well studied, those of B. parapertussis have not. The present study explores the mechanism by which B. parapertussis is cleared from the lower respiratory tract by anamnestic immunity. Serum antibodies are necessary and sufficient for elimination of this bacterium, and CD4+ T cells, complement, and neutrophils are required for serum antibody-mediated clearance. Mice lacking immunoglobulin A had no defect in their ability to control or clear infection. Interestingly, serum antibody-mediated clearance of B. parapertussis did not require Fc receptors that are required for antibody-mediated clearance of B. pertussis. Together these data support a model for the mechanism of protective immunity to B. parapertussis that is similar but distinct from that of B. pertussis.

* Corresponding author. Mailing address: 115 Henning Building, The Pennsylvania State University, University Park, PA 16802. Phone: (814) 863-8522. Fax: (814) 863-6140. E-mail: eth10{at}psu.edu.

Editor: J. N. Weiser

Infection and Immunity, October 2005, p. 6508-6513, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.6508-6513.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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