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Infection and Immunity, October 2005, p. 7014-7017, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7014-7017.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Lethal Infection of C3H/HeJ and C3H/SCID Mice with an Isolate of Leptospira interrogans Serovar Copenhageni

Jarlath E. Nally,1* Michael C. Fishbein,2 David R. Blanco,1 and Michael A. Lovett1

Department of Medicine, Division of Infectious Diseases,1 Department of Pathology and Laboratory Medicine, University of California—Los Angeles, Los Angeles, California2

Received 28 April 2005/ Returned for modification 4 June 2005/ Accepted 16 June 2005

Leptospira interrogans serovar Copenhageni strain RJ16441, a blood isolate from humans with the severe pulmonary form of leptospirosis, has previously been shown to cause fatal pulmonary hemorrhage in guinea pigs and asymptomatic chronic renal tubular colonization with urinary shedding in rats. In this study, RJ16441 caused lethal infection of both C3H/HeJ and C3H/SCID mice, but no hemorrhagic phenomena were observed.

* Corresponding author. Mailing address: University of California—Los Angeles, Department of Medicine, 37-121 CHS, Division of Infectious Diseases, 10833 Le Conte Avenue, Los Angeles, CA 90095. Phone: (310) 825-4188. Fax: (310) 825-3632. E-mail: jnally{at}mednet.ucla.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, October 2005, p. 7014-7017, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7014-7017.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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