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Infection and Immunity, October 2005, p. 7069-7073, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7069-7073.2005

Bacillus anthracis Edema Toxin Inhibits Staphylococcus aureus Enterotoxin B Effects In Vitro: a Potential Protein Therapeutic?

Teresa Krakauer,1* Stephen F. Little,2 and Bradley G. Stiles1*

Integrated Toxicology,1 Bacteriology Divisions, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-50112

Received 14 May 2005/ Returned for modification 21 June 2005/ Accepted 11 July 2005

Various in vitro effects of staphylococcal enterotoxin B (SEB) on human peripheral blood mononuclear cells were mitigated by Bacillus anthracis edema toxin. In particular, levels of some SEB-induced cytokines (tumor necrosis factor alpha, gamma interferon) and chemokines (monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha [MIP-1{alpha}], MIP-1ß) were significantly diminished or even nonexistent, depending upon the timing of edema toxin administration. Overall, these results suggest a novel use of B. anthracis edema toxin against a bacterial superantigen.

* Corresponding author. Mailing address: Integrated Toxicology Division, USAMRIID, Fort Detrick, MD 21702-5011. Phone for Bradley G. Stiles: (301) 619-4809. Fax: (301) 619-2348. E-mail: bradley.stiles{at}amedd.army.mil. Phone for Teresa Krakauer: (301) 619-4733. Fax: (301) 619-2348. E-mail: teresa.krakauer{at}amedd.army.mil.

Editor: J. T. Barbieri

Infection and Immunity, October 2005, p. 7069-7073, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7069-7073.2005




This article has been cited by other articles:

  • Sherer, K., Li, Y., Cui, X., Eichacker, P. Q. (2007). Lethal and Edema Toxins in the Pathogenesis of Bacillus anthracis Septic Shock: Implications for Therapy. Am. J. Respir. Crit. Care Med. 175: 211-221 [Abstract] [Full Text]  


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