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Infection and Immunity, November 2005, p. 7436-7441, Vol. 73, No. 11
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.11.7436-7441.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CD28 Is Required for Optimal Induction, but Not Maintenance, of Vaccine-Induced Immunity to Blastomyces dermatitidis

Marcel Wüthrich,1* Tom Warner,2 and Bruce S. Klein1,3,4,5

Department of Pediatrics,1 Department of Pathology and Laboratory Medicine,2 Department of Internal Medicine,3 Department of Medical Microbiology and Immunology,4 Comprehensive Cancer Center, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 537925

Received 10 March 2005/ Returned for modification 6 April 2005/ Accepted 27 July 2005

Cellular immunity mediated by T lymphocytes, in particular CD4+ and CD8+ type 1 cells, is the main defense against pathogenic fungi. Here, CD28-deficient (CD28–/–) mice were used to study the role of costimulation for the generation and maintenance of T-cell-mediated, type 1 cytokine-dependent mechanisms of vaccine immunity to Blastomyces dermatitidis infection. Disruption of CD28 costimulation reduced the number of type 1 CD4 and CD8 cells generated and impaired resistance to infection. Type 1 T-cell subsets generated in vaccinated CD28–/– mice were durable and protected mice for at least 3 months after vaccination. Our findings suggest that CD28 is required for the induction of optimal, protective T-cell responses to B. dermatitidis infection but may be dispensable for the maintenance of T-cell memory.

* Corresponding author. Mailing address: University of Wisconsin Hospitals and Clinics, 600 Highland Ave., K4/444, Madison, WI 53792. Phone: (608) 263-6203. Fax: (608) 263-0440. E-mail: mwuethri{at}wisc.edu.

Editor: T. R. Kozel

Infection and Immunity, November 2005, p. 7436-7441, Vol. 73, No. 11
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.11.7436-7441.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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