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Infection and Immunity, November 2005, p. 7779-7783, Vol. 73, No. 11
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.11.7779-7783.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The IncP Island in the Genome of Brucella suis 1330 Was Acquired by Site-Specific Integration

Jean-Philippe Lavigne, Annette C. Vergunst, Gisèle Bourg, and David O'Callaghan*

Institut National de la Santé et de la Recherche Médicale, Unité 431, UFR de Médecine, CS 83021, Avenue J. F. Kennedy, 30908 Nimes Cedex 02, France

Received 11 March 2005/ Returned for modification 11 April 2005/ Accepted 25 July 2005

An 18,228-bp region containing open reading frames predicted to be derived from the IncP plasmid or phage ancestors is present in the genomes of Brucella suis biovars 1 to 4, B. canis, B. neotomae, and strains isolated from marine mammals, but not in B. melitensis, B. abortus, B. ovis, and B. suis biovar 5. The presence of circular excision intermediates and the results of an analysis of sequenced bacterial genomes suggest that the region downstream of the guaA gene is a hotspot for site-specific integration of foreign DNA mediated by a CP4-like integrase.

* Corresponding author. Mailing address: Institut National de la Santé et de la Recherche Médicale, Unité 431, UFR de Médecine, CS 83021, Avenue J. F. Kennedy, 30908 Nimes Cedex 02, France. Phone: 33 4 66 02 81 46. Fax: 33 4 66 02 81 48. E-mail: david.ocallaghan{at}univ-montp1.fr.

Editor: D. L. Burns

Infection and Immunity, November 2005, p. 7779-7783, Vol. 73, No. 11
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.11.7779-7783.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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