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Infection and Immunity, December 2005, p. 8444-8448, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8444-8448.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Azurin of Pathogenic Neisseria spp. Is Involved in Defense against Hydrogen Peroxide and Survival within Cervical Epithelial Cells

Hsing-Ju Wu,1,{dagger} Kate L. Seib,1 Jennifer L. Edwards,2,{ddagger} Michael A. Apicella,2 Alastair G. McEwan,1 and Michael P. Jennings1*

The School of Molecular and Microbial Sciences and Centre for Metals in Biology, The University of Queensland, Brisbane 4072, Australia,1 Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 522422

Received 13 May 2005/ Returned for modification 3 June 2005/ Accepted 26 August 2005

Laz, a lipid-modified azurin of the human pathogens Neisseria gonorrhoeae and Neisseria meningitidis, is involved in defense against oxidative stress and copper toxicity; laz mutant strains are hypersensitive to hydrogen peroxide and copper. The N. gonorrhoeae laz mutant also has decreased survival in an ex vivo primary human ectocervical epithelial assay.

* Corresponding author. Mailing address: The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia. Phone: 61 7 3365 4879. Fax: 61 7 3365 4620. E-mail: jennings{at}uq.edu.au.

Editor: J. N. Weiser

{dagger} Present address: Core Facilities for Proteomics Research, Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.

{ddagger} Present address: Centre for Microbial Pathogenesis, Columbus Children's Research Institute, Columbus, OH 43205.

Infection and Immunity, December 2005, p. 8444-8448, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8444-8448.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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